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All three maois (isocarboxazid, phenelzine and tranylcypromine), available in the u.s Isocarboxazid is used to treat symptoms of depression that may include anxiety, panic, or phobias. And used for the treatment of depression, are irreversible inhibitors of the enzyme monoamine oxidase.

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Monoamine oxidase inhibitors (maois) maois block the effects of monoamine oxidase enzymes, and increases levels of dopamine, norepinephrine, and serotonin in the brain. Isocarboxazid is a monoamine oxidase inhibitor (maoi) that works by increasing the levels of certain chemicals in the brain Other types include tricyclic antidepressants (tcas), serotonin and norepinephrine reuptake inhibitors (snris), norepinephrine and dopamine reuptake inhibitors (ndris), monoamine oxidase inhibitors (maois), and the atypical antidepressants.

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Drugs that replace dopamine are generally given with peripherally acting dopa carboxylase inhibitors, to prevent the metabolism of levodopa to dopamine peripherally

Dopamine receptor agonists bind to dopamine receptors and mimic the action of dopamine. Snris increase levels of serotonin and norepinephrine in the brain by blocking or delaying their reuptake by nerves. Various mao inhibitors have been found to have antidepressant action (e.g., isocarboxazid, iproniazid, phenelzine, tranylcypromine) However, the only mao inhibitors currently commercially available in the us for use as antidepressant agents are phenelzine and tranylcypromine.

Common drug classes that can cause serotonin syndrome include selective serotonin reuptake inhibitors (ssris), monoamine oxidase inhibitors (maois), and opioids like tramadol. Nardil is a monoamine oxidase inhibitor (maoi) that is used to treat symptoms of atypical depression in adults when other medicines have not been effective Nardil is not for treating severe depression or bipolar disorder (manic depression).